Three product lines. Three mechanisms. One unified architecture. A surgeon‑engineered system that treats the mouth as a controllable origin node of systemic inflammation.
From Greek lysis — targeted dissolution. Hunt and eliminate. Spare everything else.
A two‑stage tray‑applied biofilm intervention system. Stage 1 (BREACH) uses hydrogen peroxide effervescence plus enzymatic matrix degradation — DNase I, Dispersin B, Proteinase K — to collapse biofilm architecture in 5–10 minutes. Stage 2 (HUNT) deploys bacteriophages targeting P. gingivalis, T. forsythia, and A. actinomycetemcomitans, plus recombinant endolysins and lactoferrin, delivered in a dual‑weight hyaluronic acid matrix for sustained contact and tissue support.
H₂O₂ effervescence disrupts biofilm oxygen gradients. DNase I degrades extracellular DNA scaffold. Dispersin B hydrolyzes PNAG adhesin matrix. Proteinase K cleaves surface-bound adhesion proteins. Combined: 4.5 log colony reduction.
Species-specific bacteriophages bind exclusively to bacterial surface receptors. Recombinant endolysins degrade peptidoglycan from outside. Lactoferrin sequesters iron from pathogen metabolism. HA carrier ensures 4+ hours mucosal residence time.
From Greek lithos — stone. What teeth are meant to be. Rebuild, don't just protect.
Built on Professor Alvaro Mata's elastin‑like recombinamer (ELR) technology from the University of Nottingham, published in Nature Communications (November 2025). Lithos drives epitaxial hydroxyapatite crystal growth in native enamel orientation — not amorphous mineral deposition, but organized crystallographic reconstruction from the lattice up.
Elastin-like recombinamers provide a protein scaffold that templates hydroxyapatite nucleation at the demineralized surface. Epitaxial growth — crystals form in the same orientation as native enamel prisms. Not a coating. True structural integration at the molecular level.
Mata's ELR is the mineralization engine. Fasolati's dual-weight HA carrier is the delivery and mucosal integration layer. Lithos combines both: mineralization scaffold + bio-adhesive matrix for complete tooth reconstruction.
From Latin luere — to purify. The original Fasolati formulation. Physical barrier, heal, hydrate, and hold.
Loria replaces chlorhexidine's indiscriminate kill with intelligent ecological remodeling. Biofilm‑dispersing enzymes dismantle the extracellular polysaccharide scaffold. Dual‑weight hyaluronic acid creates a physical barrier while driving fibroblast proliferation by 35% within 7 days. Castor oil reduces IL‑1β and TNF‑α while reinforcing pellicle lipid barriers. Bio‑adhesive film formation via pullulan and PVP ensures hours of therapeutic residence.
High MW HA forms protective scaffolding on mucosal surface. Low MW HA penetrates deeper tissue, stimulates fibroblast proliferation, drives re-epithelialization (8/9 wounds healed in 24 hours vs 0/9 saline).
Dual-weight HA retains moisture at mucosal surfaces. Pullulan + PVP create cross-linked adhesion network for extended therapeutic residence. CPC at 0.05% provides selective antimicrobial baseline.
Maxoral and Fasolati are not products. They're distribution tiers that determine formulation strength, regulatory class, and channel strategy.
Prescription-strength formulations. Higher enzyme concentrations, full phage payloads (when cleared), extended-release tray application. Distributed through DSOs, periodontists, oral surgeons via Henry Schein, Patterson, Benco.
Consumer formulations optimized within OTC regulatory limits. D2C, Amazon, pharmacy, subscription. Daily Loria maintenance, Lithos remineralization kits, Stage 1 Lytica enzyme gel. The recurring revenue engine.
Lytica, Lithos, and Loria are not three separate products. They are a clinical protocol.
Clear the active infection. Breach the biofilm. Eliminate keystone pathogens. Reset the ecology.
Restore what disease destroyed. Regenerate enamel. Reconstruct mineral density from the lattice up.
Maintain the ecology daily. Disrupt biofilm reformation. Barrier, heal, hydrate, hold. Indefinitely.
DSOs deploy this as a complete system of care. Lytica is the high-margin intervention. Lithos is the upsell. Loria is the recurring subscription revenue stream.
You deserve to know exactly how the AI that manages your health actually works — what it knows, where it learned it, how it checks itself, and how it gets smarter the longer you use it.
Not a chatbot. A clinical reasoning engine trained on the science of inflammation.
SciAgent is built on a large language model — the same class of AI behind the most advanced reasoning systems in the world — but fine-tuned specifically for oral-systemic health. Think of the base model as a medical school graduate: broad knowledge, strong reasoning. Our fine-tuning is the residency — years of specialized training in the exact pathways that connect your mouth, your gut, and your systemic inflammation.
A state-of-the-art language model provides the reasoning backbone — the ability to read your data, recognize patterns, weigh tradeoffs, and explain its thinking in plain language. We don't build this from scratch. We build on the best.
We then train the model on oral-systemic health specifically: periodontal pathology, gut barrier dynamics, inflammatory cascades, biomarker interpretation, pharmacology of our product lines. It doesn't guess about inflammation. It reasons from mechanism.
SciAgent can only recommend interventions from the Fasolati product ecosystem. It cannot prescribe medications, diagnose diseases, or replace your doctor. It operates within strict clinical guardrails — what to rinse, swallow, and avoid. Not medical advice. Protocol guidance.
Every recommendation SciAgent makes comes with a "why." Not a black box output — a transparent chain of reasoning you can read, question, and share with your clinician. If it suggests increasing your Loria frequency, it tells you exactly which data point triggered that change.
Trained on peer-reviewed science. Not internet health forums. Not sponsored content.
The quality of an AI is only as good as the quality of its training data. SciAgent's knowledge base is built from curated, peer-reviewed clinical literature — the same sources your periodontist and gastroenterologist rely on. We don't scrape the internet. We curate the science.
Thousands of peer-reviewed papers on periodontitis, gut permeability, inflammatory biomarkers, microbiome ecology, and the oral-systemic connection. Sources include The Lancet, Nature, Journal of Clinical Periodontology, Gut, and specialized inflammation research.
Reference ranges, population distributions, and clinical significance thresholds for hs-CRP, HbA1c, zonulin, calprotectin, LPS-binding protein, and other inflammatory markers. SciAgent knows what your numbers mean in context — not just whether they're "high" or "low."
Deep knowledge of every Fasolati formulation — mechanisms, dosing, interactions, contraindications, expected response curves. When SciAgent adjusts your Lytica protocol, it understands the enzymatic and phage mechanisms at the molecular level.
Current treatment guidelines from the American Academy of Periodontology, American Gastroenterological Association, and the European Federation of Periodontology. SciAgent's recommendations align with — never contradict — established standards of care.
What SciAgent is never trained on: social media health claims, supplement marketing, anecdotal testimonials, or unreviewed preprints. If it's not in the peer-reviewed literature or validated clinical databases, SciAgent doesn't know it — and that's by design.
Every recommendation runs through three layers of verification before it reaches you.
We built SciAgent with a fundamental assumption: AI makes mistakes. The question isn't whether errors happen — it's whether the system catches them before they reach you. Our answer is a three-layer verification architecture that treats every output as unproven until confirmed.
Evidence Match
Every claim is cross-referenced against its source literature. If SciAgent says "hs-CRP above 3.0 correlates with increased cardiovascular risk," it must cite the specific studies.
Clinical Guardrails
Rule-based safety checks catch anything outside established parameters. Dosing limits, contraindication flags, interaction warnings — hard-coded, not learned. The AI cannot override these.
Confidence Scoring
Every recommendation carries a confidence score. High confidence: act on it. Medium: SciAgent explains the uncertainty. Low: it flags the question for your clinician instead of guessing.
SciAgent cannot fabricate studies or statistics. It retrieves from its verified knowledge base or says "I don't know."
If your data suggests something outside its scope — a possible diagnosis, a medication question — it routes you to your doctor, not a guess.
Every recommendation is logged with its reasoning chain. Your clinician can review exactly why SciAgent made each suggestion.
The longer you use Fasolati, the smarter your personal model becomes.
SciAgent starts with population-level science — what works for most people. But you're not most people. Over weeks and months, it builds a model of your specific inflammatory patterns, your response curves, your habits, and your triggers. This is where it transforms from a general tool into your personal health engine.
SciAgent ingests your initial data: lab results, oral exam findings, any wearable data you connect. It establishes your personal baseline across the three vectors — Oral Ecology, Gut Integrity, Systemic Inflammation — and sets starting protocols based on population evidence.
As you use the products and log data, SciAgent begins tracking how your body responds. How quickly does your hs-CRP drop after a Lytica intervention? Does your sleep quality correlate with gut protocol adherence? It's building your personal response curves.
With enough data, SciAgent starts identifying your unique patterns. Maybe your inflammation spikes every time you travel. Maybe your oral ecology dips on weekends. Maybe Biolumen works faster for you than population averages predict. These insights shape increasingly precise protocols.
This is where the model matures. SciAgent begins anticipating inflammatory events before they show up in your biomarkers — adjusting protocols proactively based on behavioral patterns, seasonal trends, and your established response curves. It moves from reactive to predictive.
Your model never stops learning. Every new lab result, every oral exam, every week of wearable data sharpens the picture. And as the broader Fasolati user base grows, anonymized population insights feed back into the system — your model benefits from the collective without ever exposing your data.
Your health data is yours. Period.
Your personal health data is encrypted with AES-256 encryption — the same standard used by banks and defense systems. Even our engineers cannot read your individual records.
Your data is never sold, rented, or shared with advertisers, insurance companies, or employers. Fasolati's business model is products and subscriptions — not your information.
Export your complete health record anytime. Delete your data anytime. Pause data collection anytime. Your model, your data, your decision.
If you opt in, anonymized and de-identified patterns from your data contribute to population-level research that improves the system for everyone. No identifying information ever leaves your account.
Whether you're a clinician, investor, DSO operator, or researcher — tell us how you want to connect and we'll get back to you within 48 hours.
Get early access to Lytica, Lithos, and Loria professional products. Integrate the Fasolati Engine into your practice workflow. See how oral-systemic protocols reduce inflammatory markers in your patient population.
Fasolati sits at the intersection of oral health ($50B), gut health ($71B), and AI-driven precision medicine. We're building the operating system for inflammation prevention — the largest addressable cause of death globally.
Deploy the full Lytica → Lithos → Loria therapeutic cascade across your network. New high-margin intervention revenue plus recurring Fasolati subscriptions that increase patient lifetime value.
Access de-identified longitudinal data from the Fasolati platform. Collaborate on oral-systemic, microbiome, and biomarker studies with real-world evidence from active patient populations.
Get updates on product launches, research findings, and partnership opportunities as the Fasolati node network expands.
Your information is encrypted and never shared. We'll respond within 48 hours.
Thanks for reaching out. Your information has been received and someone from the Fasolati team will be in touch within 48 hours. In the meantime, explore the platform:
Clinical-grade oral and gut health — available now or join the waitlist for early access to products in development.
The original Fasolati oral formulation. Barrier, heal, hydrate, hold — every day.
Dual-weight hyaluronic acid mucosal barrier system. Replaces chlorhexidine with intelligent ecological remodeling. High MW HA blocks bacterial adhesion while low MW HA stimulates fibroblast proliferation and accelerates wound healing. Bio-adhesive film ensures hours of therapeutic residence — not the 30 seconds of a standard rinse.
240mL bottle
30-day supply
Twice daily
Rinse 60 seconds
Dual-weight HA
Castor oil · CPC · Pullulan
Biomimetic enamel reconstruction from the lattice up. Not a coating — true structural integration.
Built on Alvaro Mata's elastin-like recombinamer technology. At-home application kit for early caries, erosive wear, post-whitening sensitivity, and white spot lesions. Professional-strength version available through your dental provider.
Two-stage enzyme + phage biofilm disruption. Ask your periodontist about Lytica.
Professional-dispensed tray application system. Stage 1 enzymatic matrix degradation followed by Stage 2 targeted bacteriophages. For active periodontal disease, peri-implantitis, and refractory cases. Available through the Maxoral professional channel.
Magisnat · Biolumen · Monch Monch — the second origin node, addressed.
Anti-inflammatory nutraceuticals, precision prebiotic fibers, and metabolic snacks designed to restore gut barrier integrity and microbiome diversity. Three products, one protocol — matched to your Fasolati Engine gut integrity score.
Three-vector scoring, SciAgent AI protocols, biomarker tracking — your personal inflammation operating system.
Connect your labs, wearables, and oral exam data. SciAgent builds your personal inflammatory model and writes daily protocol orders. Subscription includes Engine access, protocol updates, and priority access to new products as they launch.
Fasolati started with a simple observation in an operating room: the mouth and the body have never been treated as one connected system. We're changing that.
For nearly two decades, Dr. Thad Connely has operated at the intersection of the mouth and the body — as an oral and maxillofacial surgeon performing total joint reconstructions, treating the most severe manifestations of what happens when oral disease goes systemic.
The pattern was always the same: patients arriving with advanced disease that started as inflammation nobody monitored. Periodontitis that seeded systemic infection. Gut dysbiosis that accelerated joint destruction. Biomarkers that were never checked until the damage was done.
The insight wasn't that these systems were connected — the literature has shown that for decades. The insight was that nobody had built the infrastructure to treat them as one system. No product line spanned both origin nodes. No AI correlated the data across domains. No protocol existed that told a patient what to rinse, swallow, and avoid — today, based on their specific inflammatory profile.
Fasolati is that infrastructure. Built by a surgeon who got tired of operating on problems that should have been intercepted upstream.
Three out of five people die of chronic inflammatory diseases. The mouth and the gut are the two origin nodes where that inflammation begins — and the two places where it can actually be intercepted before it becomes cardiovascular disease, neurodegeneration, metabolic syndrome, or autoimmune destruction.
The body is a connected system. Oral health, gut health, and systemic inflammation are not three separate problems — they're one network. Fasolati is built to treat the network.
Vague wellness recommendations fail. Specific, daily, data-driven protocols succeed. SciAgent doesn't suggest you "eat better" — it tells you exactly what to do today based on your data.
The same mechanisms used in the operating room — enzymatic biofilm disruption, phage therapy, HA tissue engineering — delivered as daily consumer products anyone can use.
Every recommendation comes with a "why." Every data point is yours. Every algorithm is auditable. We built "Inside the Black Box" because trust isn't a feature — it's the foundation.
Nearly a decade of oral and maxillofacial surgery across thousands of cases. Pattern recognition: the mouth-body disconnect in clinical practice is systemic, not anecdotal. The problem isn't knowledge — it's infrastructure.
Development of the dual-weight hyaluronic acid platform. First prototypes of what would become Loria — a chlorhexidine replacement that heals instead of kills. Early clinical validation of the mucosal barrier approach.
The realization that a single oral rinse wasn't enough. The mouth-gut-systemic framework takes shape. Partnerships with Magisnat (nutraceuticals), phage therapy researchers, and the Mata lab at Nottingham for enamel regeneration.
The platform crystallizes: three oral product lines (Lytica, Lithos, Loria), three gut products (Magisnat, Biolumen, Monch Monch), two distribution tiers (Maxoral Rx, Fasolati OTC), and the SciAgent AI engine tying it all together.
Mata's ELR enamel regeneration technology published in Nature Communications. Lithos integration begins — the first product in the world to offer true biomimetic enamel reconstruction outside a lab setting.
Loria goes to market. Fasolati Engine enters beta. DSO partnerships activate. The node network goes from architecture to operating system. The unlit corner starts to glow.
Oral · Gut · Systemic
"Oral health is the last unlit corner of systemic health."
Fasolati is an AI‑driven platform that treats the mouth and gut as origin nodes of systemic inflammation, wiring oral therapeutics, gut repair, and biomarker‑driven protocols into a single operating system for human health.
Not advice, an engine. Not a product line, a node network.
01 — The Case
Three out of five people die of chronic inflammatory diseases. The mechanism is distributed, poorly surveilled, and rarely discussed with the precision of something like LDL—even though hs‑CRP is a validated, cheap, and underused early warning.
02 — Origin Node One
The periodontal pocket is not a local nuisance; it is a vascularized wound that leaks inflammatory signals and pathogens into systemic circulation, liver, endothelium, placenta, and brain.
A surgeon‑engineered oral therapeutics line that treats the mouth as a controllable origin node of systemic inflammation.
03 — Origin Node Two
The intestinal barrier is a dynamic border. When it fails—through diet, dysbiosis, or oral pathogen seeding—lipopolysaccharides and inflammatory mediators leak into circulation, driving hepatic inflammation, insulin resistance, and neurodegeneration.
Mediterranean nutraceuticals, prebiotic fibers, and metabolic snacks built to restore barrier integrity and microbiome diversity, not just macronutrients.
04 — The Engine
The Fasolati Engine treats hs‑CRP, nitric oxide, and HbA1c like actual vital signs. It ingests biomarker panels, oral exams, and lifestyle signals, then uses SciAgent to convert those into protocol‑level instructions instead of vague advice.
Three Vectors, One Score
Oral Ecology, Biofilm Load, Gingival Health.
Gut Integrity, Barrier Function, Microbiome Diversity.
Inflammation Control, Nitric Oxide Bioavailability, Mitochondrial Function.
SciAgent: Inputs → Patterns → Protocols
SciAgent correlates patterns like CRP spikes with poor sleep, dietary errors, or missed rinses and writes simple daily orders: what to rinse, swallow, and avoid—today.
Labs, wearables, oral photographs, clinical notes.
Multi‑week correlations, threshold crossings, response curves.
A living checklist for today, this week, this quarter.
05 — The Network
Fasolati is not a single product. It is a network of nodes—oral, gut, systemic—plugged into a shared data and protocol layer.
Pilot Fasolati in your practice or study. Wire oral exams, gut protocols, and biomarker panels into one engine and watch inflammatory risk become visible.
Help build the node network: scale Fasolati across oral health, metabolic clinics, digital health platforms, and chronic disease prevention programs.